From 1st May, The Biltmore Mayfair will end its partnership with Hilton and and move to operating as an independent hotel.
The 307-room hotel located on Grosvenor Square in London opened in 2019 following a £50m redevelopment of the former Millenium Hotel London Mayfair.
It was the first site in Europe for Hilton's luxury LXR Hotels & Resorts brand, with room rates starting from £550 a night.
With The Biltmore Mayfair's transition to operating independently, Hilton will no longer have any properties in the UK under its LXR Hotels brand.
A statement on behalf of the Biltmore said the hotel had enjoyed a 'productive partnership' with Hilton, but would now be fully overseen by managing director Vella Ramasawmy.
It said the change was part of the management team's aim to 'elevate the Biltmore hotel brand and expand the Biltmore brand proposition after five successful years of operation'.
'I am very pleased to be directing the Biltmore Mayfair through this exciting transition,' said Ramasawmy. 'My priority is to ensure a seamless handover internally and externally, and for the hotel to continue offering exceptional experiences and the best service to all guests. I have no doubt my experienced team will ensure a bright future for the impeccable hotel.
'We would like to express our gratitude to Hilton for its partnership. This decision was made with careful consideration and with the goal of enhancing the guest experience and maintaining our position as one of London's top luxury hotels.'
A statement on the hotel's website said the changes meant any stays booked past 1 May would not accrue Hilton Honors points, but guests would instead be offered 'competitive loyalty benefits'.
The Biltmore Mayfair offers a 24-hour gym, all-day brasserie Café Biltmore, steakhouse Grill 88 and a tea lounge.
Jason Atherton initially launched the Betterment fine dining restaurant at the hotel in 2019. Following the pandemic, the site was rebranded as the more casual Café Biltmore.
The chef announced his departure from the hotel last year following disagreements with the ownership regarding the direction of the restaurant.
The hotel plans to launch a partnership on Café Biltmore's terrace this summer, collaborating with Champagne house Veuve Clicquot.